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FcRn: A critical player in IgG regulation1

The neonatal Fc receptor (FcRn) is present in several cell types, including vascular endothelial cells, and is responsible for recycling all kinds of IgG antibodies, reducing their clearance, and prolonging their half-life.1

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Further exploration of FcRn is warranted1

The symptoms of generalized myasthenia gravis (gMG) are generally perpetuated by IgG autoantibodies against acetylcholine receptors (AChR), muscle-specific tyrosine kinase (MuSK), and low-density lipoprotein receptor-related protein 4 (LRP4). Therefore, it may be worth exploring strategies that modulate the recycling of these IgG antibodies by FcRn.1,2

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References: 1. Roopenian DC, Akilesh S. Nat Rev Immunol. 2007;7(9):715-725. doi:10.1038/nri2155 2. Gilhus NE et al. Nat Rev Neurol. 2016;12(5):259-268. doi:10.1038/nrneurol.2016.44

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