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FcRn: a critical player in IgG regulation1

The neonatal Fc receptor (FcRn) is present in several cell types, including vascular endothelial cells, and is responsible for recycling all kinds of immunoglobulin G (IgG) antibodies, reducing their clearance, and prolonging their half-life.1


IgG and gMG

Pathogenic IgG autoantibodies target vital components of the neuromuscular junction (NMJ), including acetylcholine receptors (AChR), muscle-specific tyrosine kinase (MuSK), and low-density lipoprotein receptor-related protein 4 (LRP4).2

Further exploration of FcRn is warranted

In targeting the NMJ, pathogenic IgG autoantibodies disrupt neuromuscular transmission and drive the skeletal muscle weakness that defines gMG.3,4 Therefore, it may be worth exploring strategies that modulate the recycling of IgG antibodies by FcRn.1

Dive deeper into the role of IgG autoantibodies and FcRn-mediated antibody recycling in gMG


References: 1. Roopenian DC, Akilesh S. Nat Rev Immunol. 2007;7(9):715-725. doi:10.1038/nri2155 2. Gilhus NE et al. Nat Rev Neurol. 2016;12(5):259-268. doi:10.1038/nrneurol.2016.44 3. Huijbers MG et al. J Intern Med. 2014;275(1):12-26. doi:10.1111/joim.12163 4. Gilhus NE. N Engl J Med. 2016;375(26):2570-2581. doi:10.1056/NEJMra1602678