TEST YOUR KNOWLEDGE
TEST YOUR KNOWLEDGE
gMG is an autoimmune disorder of the musculoskeletal system caused by pathogenic immunoglobulin G (IgG) autoantibodies.1
Studies have explored targeting the neonatal Fc receptor (FcRn), as it plays a critical role in gMG by prolonging the half-life of IgG antibodies, including pathogenic antibodies.5,6
FcRn binds IgG antibodies, including pathogenic autoantibodies, rescuing them from lysosomal degradation and recycling them back into circulation.5
References: 1. Gotterer L, Li Y. J Neurol Sci. 2016;369:294-302. doi:10.1016/j.jns.2016.08.057 2. Guo Y et al. Front Immunol. 2018;9:1299. doi:10.3389/fimmu.2018.01299 3. Liu D et al. Allergy Asthma Clin Immunol. 2013;9(1):30. doi:10.1186/1710-1492-9-30 4. Gilhus NE et al. Nat Rev Dis Primers. 2019;5(1):30. doi:10.1038/s41572-019-0079-y 5. Roopenian DC, Akilesh S. Nat Rev Immunol. 2007;7(9):715-725. doi:10.1038/nri2155 6. Ward ES, Ober RJ. Trends Pharmacol Sci. 2018;39(10):892-904. doi:10.1016/j.tips.2018.07.007